We previously reported that the Centers for Medicare & Medicaid Services (CMS) will not require an order from a physician or other practitioner for a COVID-19 diagnostic test, permitting pharmacists to perform the test without a provider order. On May 8, 2020, CMS published a document clarifying how pharmacies and other suppliers can temporarily enroll as independent clinical diagnostic laboratories during the COVID-19 public health emergency using the provider enrollment hotline. Pharmacies operating drive-through and other COVID-19 diagnostic testing sites are proving to be crucial to meeting the need for COVID-19 testing.